Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 38, Issue 1, Pages 53-65Publisher
SPRINGER
DOI: 10.1007/s11164-011-0325-8
Keywords
Organotin(IV) complexes; Antimicrobial activity; Thiosemicarbazone; Semicarbazone; Spectral studies
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Reaction of dibutyltin dichloride, dimethyltin dichloride, and tributyltin chloride with ligands derived from thiosemicarbazone and semicarbazone leads to the formation of a new series of organotin(IV) complexes of general formula R2SnCl2 center dot L and R3SnCl center dot L (where L ligands derived from the condensation of thiosemicarbazide and semicarbazide with 4-hydroxy-3-methoxybenzaldehyde). The authenticity of these ligands and their metal complexes have been established on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, H-1 NMR, C-13 NMR, Sn-119 NMR, and UV spectral studies. These studies showed that the ligands coordinate to the metal atom in a bidentate. An octahedral structure is proposed for the organotin(IV) complexes. The ligands and its metal complexes are screened for their antimicrobial activities against some Gram-positive and Gram-negative bacteria, and fungus. The studies demonstrated that metalation can increase the antimicrobial activity rather than the free ligands.
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