Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 35, Issue 8-9, Pages 1005-1014Publisher
SPRINGER
DOI: 10.1007/s11164-009-0083-z
Keywords
Gene delivery; Polyamidoamine; Dendrimer; Cationic lipid; Galactose; Nonviral vector
Categories
Funding
- Ministry of Education, Science, Sports, and Culture in Japan
- Japan Society for the Promotion of Science for Young Scientists
Ask authors/readers for more resources
We have so far developed a new type of cationic lipid that consists of an amine-terminated poly(amidoamine) dendron and two long alkyl chains. In this study, we designed a dendron-bearing lipid (DL) modified with sugar moieties as the ligand at the terminal groups of the dendron to improve the transfection activities. We combined lactobionic acid at the end of every dendritic branch of the DL to produce galactose moieties-attached DL (Gal-DL). The lipoplexes containing Gal-DL exhibited enhancement of transfection of HepG2 cells. Moreover, Gal-DL significantly promoted the transfection activity of the lipoplexes including poly(ethylene glycol)-attached dendron-bearing lipid (PEG-DL).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available