Journal
RESEARCH IN VETERINARY SCIENCE
Volume 95, Issue 3, Pages 1094-1099Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2013.09.003
Keywords
EGFR; Angiogenesis; MVD; CD31; Canine mammary tumours
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Funding
- Centro de Ciencia Animal e Veterinaria (CECAV) - University of Tras-os-Montes
- Alto Douro (UTAD), Vila Real, Portugal
- Foundation for Science and Technology (FCT) [Pest-OE/AGR/UI0772/2011]
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The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor which has been shown to have an important role in human breast cancer. Its role appears to be associated with increased angiogenesis and metastasis. In order to clarify its role in canine mammary tumours (CMT), 61 malignant neoplasms were studied by using immunohistochemistry, comparing expression of EGFR, microvessel density (MVD) by CD31 immunolabelling and characteristics of tumour aggressiveness. High EGFR immunoexpression was statistically significantly associated with tumour size, tumour necrosis, mitotic grade, histological grade of malignancy and clinical stage. High CD31 immunoreactivity was statistically significantly associated with tubule formation, histological grade of malignancy and clinical stage. A positive correlation between EGFR and CD31 immunoexpression (r = 0.843; P < 0.001) was also observed. Results suggest that an over-expression of EGFR may contribute to increased angiogenesis and aggression in malignant CMT, presenting the possibility of using EGFR inhibitors in the context of metastatic disease treatment. (C) 2013 Elsevier Ltd. All rights reserved.
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