Journal
RESEARCH IN VETERINARY SCIENCE
Volume 91, Issue 3, Pages E31-E37Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2011.01.012
Keywords
Lemongrass oil; Bovine mastitis; Antibacterial; Mechanism of action; S. aureus
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Funding
- Graduate School Khon Kaen University, Khon Kaen, Thailand
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The aims of this study were to investigate the antibacterial activity of lemongrass oil (LG) and its major components which were citral, geraniol and myrcene, against four strains of clinically isolated bovine mastitis pathogens, including Staphylococcus aureus, Streptococcus agalactiae, Bacillus cereus and Escherichia colt by the broth microdilution method, as well as their activity on S. aureus biofilm formation. Attempts to clarify their mechanisms of action by investigation of the effects on intracellular material leakage and morphological changes of S. aureus DMST 4745 were also made. The results demonstrate that S. agalactiae and B. cereus are more susceptible to LG, citral and geraniol than S. aureus and E. coli. Moreover, they also inhibit S. aureus biofilm formation and exhibit effective killing activities on preformed bio-films. The LG appears to have multiple targets in the bacterial cell, depending on concentration used as well as the amount of its components. (C) 2011 Elsevier Ltd. All rights reserved.
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