Journal
RESEARCH IN VETERINARY SCIENCE
Volume 89, Issue 3, Pages 332-339Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2010.04.012
Keywords
Apoptosis; Cytokines; Mice; Pathology; Pasteurella multocida
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Funding
- Indian Council of Agricultural Research
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Mice were experimentally infected with Pasteurella multocida serotype A1 to study the cytokine profiles, host cell apoptosis and sequential pathology at different hours of post-infection. Infected mice were dull, anorectic and depressed. A transient leukocytopenia followed by progressive leukocytosis was observed in the course of infection. Serum cytokine profiles showed significantly (P < 0.01) higher amount of proinflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and mouse KC) in the infected mice when compared to control mice. The circulating lymphocytes were apoptotic on annexin V staining. Apoptotic nuclei were detected in splenocytes, hepatocytes and infiltrating leukocytes of the lungs on TUNEL staining. The lungs were grossly congested and hemorrhagic, and showed infiltration with polymorphonuclear cells at early and mononuclear cells in the late hours of infection. Alveolar epithelia, inter-alveolar septa and capillary endothelium of the lungs showed ultrastructural changes. Liver had degenerative changes in histological and ultrathin sections. Published by Elsevier Ltd.
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