Journal
RESEARCH IN VETERINARY SCIENCE
Volume 87, Issue 3, Pages 380-388Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2009.04.010
Keywords
Neonatal piglets; Social isolation; Stress hormones; Lymphocyte subpopulations; Cytokines
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Funding
- German Research Foundation [KA 1266/4-1]
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The aim of the study was to determine the effects of a single social isolation (4 h) of piglets on immediate changes in stress hormones and immune responses at 7, 21 or 35 days of age. This social stressor caused an increase in plasma ACTH and cortisol concentrations and a decrease in plasma TNF-alpha. The percentage of CD8(+) cells increased and the CD4(+) cell percentage decreased, resulting in decreasing CD4(+)/CD8(+) ratio. The observed changes were consistent for all days studied. Further, the isolation treatment resulted in diminished LPS-stimulated IL-1 beta and IL-10 production in whole-blood cultures. In isolated piglets, positive correlations were estimated between changes in percentage of CD8(+) cells and cortisol, and negative ones between changes in plasma TNF-alpha and culture supernatant IL-1 beta with ACTH and cortisol. The data suggest that psychosocial stress in neonatal pigs induced immune alterations to maintain adaptive stability, but reflecting also negative emotions experienced by this treatment. (c) 2009 Elsevier Ltd. All rights reserved.
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