Journal
RESEARCH IN VETERINARY SCIENCE
Volume 86, Issue 3, Pages 438-442Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2008.10.002
Keywords
Necrotizing meningoencephalitis; Pug dog encephalitis; Canine genetic disease; Canine encephalitis; Central nervous system disease
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Funding
- American Kennel Club-Canine Health Foundation [640]
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Necrotizing meningoencephalitis (NME) in the Pug is an invariably fatal disease with an early age of onset whose cause remains unknown. Breed predilection strongly suggests genetic component(s), and viral etiology proves negative in studied cases. The current study was undertaken as the first analysis of the heritable component(s) involved in NME in the Pug. Complete medical records, individual characteristics, and pedigree information were collected for 58 affected dogs with data pertaining to 4698 dogs analyzed. A high inbreeding coefficient with differences across gender and significant differences across coat color classes and variable expression was evident. Median onset age was 19 months and median survival time 23 days. Screening for herpes-, adeno-, and parvoviruses was negative. The data demonstrate a strong familial inheritance of NME in the Pug. This investigation provides parameters of disease from the largest Pug NME cohort analyzed to date and offers evidence of previously unrecognized familial inheritance. (C) 2008 Elsevier Ltd. All rights reserved.
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