Journal
RESEARCH IN VETERINARY SCIENCE
Volume 87, Issue 1, Pages 47-52Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2008.12.012
Keywords
Haemophilus parasuis; Glasser's disease; Pig; Cytokines; Vaccine
Categories
Funding
- Spanish Ministry of Education and Science [AGL2005-01210/GAN]
- Spanish Ministry
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The expression of several cytokines in spleen, pharyngeal lymph nodes, lung and brain after different immunization procedures and a challenge with 5 x 10(9) CFU of Haemophilus parasuis was compared. Five groups of colostrum-deprived pigs were used: vaccinated with (I) a bacterin, (11) an outer-membrane-protein-vaccine, (III) a recombinant transferring-binding protein B, (IV) exposed to a total dose of 10(5) CFU, and (V) not previously immunized. All pigs in groups III and V died, while all animals in group 1, most of group IV and half of group II survived until the end of the experiment. IL-1 alpha was found in significantly higher levels (p < 0.05) in spleen, lymph nodes and brain of dead pigs, which could be explained by the major severity of lesions in these animals. However, IL-4 IL-10, TNF-alpha and IFN-gamma were expressed in significantly higher levels by survivors (for all the four cytokines in lymph nodes; for IL-4, IL-10 and TNF-alpha in spleen; for IL-4, TNF-alpha and IFN-gamma in lung, and only for TNF-alpha in brain), thus suggesting a role of these four cytokines in the adaptive response, which might contribute to protection against H. parasuis infection. (C) 2008 Elsevier Ltd. All rights reserved.
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