LmrP from Lactoccoccus lactis: a tractable model to understand secondary multidrug transport in MFS

The secondary transporter LmrP from Lactoccoccus lactis is a remarkable model to study the molecular basis of secondary multidrug transport. This review article addresses more than twenty years of research about transport activity, substrates range, conformational dynamics and mechanistic models of drug export for LmrP. Several studies have shown that the transporter alternates between inward-open and outward-open conformations and that the transition is regulated by the protonation state of key acidic residues and is further modulated by the lipid environment. (C) 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.