Journal
RESEARCH IN MICROBIOLOGY
Volume 164, Issue 6, Pages 497-504Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2013.03.007
Keywords
SRP; SecYEG; Post-translational secretion; Co-translational secretion; Gene fusions
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Funding
- NIGMS NIH HHS [R01 GM041883] Funding Source: Medline
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The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial periplasm and outer membrane was the first secretion pathway to be discovered in bacteria. A combination of bacterial genetics, development of an in vitro membrane vesicle system and the concurrent elaboration of the signal hypothesis from studies on eukaryotes led to the identification and characterization of two pathways leading to protein export through the SecYEG cytoplasmic membrane translocon. The Sec pathway is also required for assembly of proteins into the cytoplasmic membrane. Since the membrane translocon for Sec pathways is conserved across the three domains of life, the history of research progress in eukaryotes and bacteria was facilitated by the close interaction between those studying both classes of organisms. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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