Journal
RESEARCH IN MICROBIOLOGY
Volume 164, Issue 6, Pages 640-654Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2013.03.017
Keywords
Type VI secretion; Bacterial protein secretion; Bacterial competition; Virulence; Secreted effector
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Funding
- Royal Society of Edinburgh/Scottish Government Personal Research Fellowship
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The Type VI secretion system (T6SS) is the most recently described of the Gram-negative bacterial secretion systems and is widely distributed amongst diverse species. T6SSs are currently believed to be complex molecular machines which inject effector proteins into target cells and which incorporate a bacteriophage-like cell-puncturing device. T6SSs have been implicated in eukaryotic cell targeting and virulence in a range of important pathogens. More recently, 'antibacterial' T6SSs have been reported, which are used to efficiently target competitor bacterial cells by the injection of antibacterial toxins. Although it is clear that T6SSs can be deployed as versatile weapons to compete with other bacteria or attack simple or higher eukaryotes, much remains to be determined about this intriguing system. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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