Journal
RESEARCH IN MICROBIOLOGY
Volume 162, Issue 3, Pages 279-284Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2010.10.010
Keywords
Acinetobactin; Feo system; Heme uptake; Siderophore
Categories
Funding
- EU
- Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/43420/2008]
- UK Medical Research Council [RA0119]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/43420/2008] Funding Source: FCT
Ask authors/readers for more resources
New putative iron-uptake genes were identified in published genomes of the opportunistic human pathogen Acinetobacter baumannii, and their occurrence was determined in a genotypically distinct collection of 50 clinical isolates by PCR and Southern blot assays. The results demonstrated that all A. baumannii isolates tested share the coding potential for two endogenous siderophores, a heme-acquisition and a ferrous iron-uptake system. A second heme-uptake cluster was detected in almost two thirds of isolates, without any apparent correlation with the clonal lineage of the strains. The wide distribution of multiple iron-acquisition systems among diverse A. baumannii clinical isolates argues for a contribution of iron uptake to the pathogenicity of this species. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available