Journal
RESEARCH IN MICROBIOLOGY
Volume 160, Issue 9, Pages 667-676Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2009.08.014
Keywords
ClpXP; RpoS; RssB; Sigma factor; Starvation; Two-component system
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Funding
- Deutsche Forschungsgemeinschaft [SPP 1132, He 1556/10]
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The sigma(S) (RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli. Regulation of sigma(S) occurs at the levels of transcription, translation, proteolysis and protein activity. As sigma(S) has become a paradigm for regulated proteolysis in bacteria, this review summarizes our current knowledge about the molecular mechanisms and multiple signal integration in sigma(S) degradation. (C) 2009 Elsevier Masson SAS. All rights reserved.
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