AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines

FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes. (C) 2009 Elsevier Masson SAS. All rights reserved.