4.3 Review

Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level

Journal

RESEARCH IN MICROBIOLOGY
Volume 160, Issue 4, Pages 278-287

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2009.03.004

Keywords

Noncoding RNAs; RNA chaperone Hfq; DsrA; RyhB; RNAIII; ABC transport systems; Iron homeostasis; Outer membrane proteins; Virulence factors; Salmonella; Stapylococcus aureus

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Funding

  1. DFG Priority Program [SPP1258]
  2. Boehringer Ingelheim Fonds, Germany

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Small noncoding RNAs (sRNAs), often in conjunction with Hfq protein, have increasingly been shown to regulate multiple rather than individual mRNAs, thereby reprogramming gene expression at the post-transcriptional level. This review summarizes how and when several such regulators (CyaR, DsrA, GcvB, OmrAB, RNAIII, RybB, RyhB) act upon multiple targets. (C) 2009 Elsevier Masson SAS. All rights reserved.

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