Journal
RESEARCH IN MICROBIOLOGY
Volume 160, Issue 9, Pages 629-636Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2009.08.018
Keywords
AAA protein; Clp/Hsp100; N-end rule; Protein quality control; Proteolysis
Categories
Funding
- Deutsche Forschungsgemeinschaft priority program
- Fonds der Chemischen Industrie
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General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins. (C) 2009 Elsevier Masson SAS. All rights reserved.
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