Journal
RESEARCH IN MICROBIOLOGY
Volume 159, Issue 5, Pages 332-339Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2008.04.008
Keywords
Mycobacterium; virion morphotype; siphoviridae; myoviridae; genome mosaicism
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Funding
- NIGMS NIH HHS [R01 GM051975, R01 GM051975-08S1] Funding Source: Medline
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The recognition of the vast numbers of bacteriophages in the biosphere has prompted a renewal of interest in understanding their morphological and genetic diversity, and elucidating the evolutionary mechanisms that give rise to them. We have approached these questions by isolating and characterizing a collection of mycobacteriophages that infect a common bacterial host, Mycobacterium smegmatis. Comparative genomic analysis of 50 mycobacteriophages shows that they are highly diverse, although not uniformly so, that they are pervasively mosaic with a multitude of single gene modules, and that this mosaicism is generated through illegitimate recombination. (C) 2008 Elsevier Masson SAS. All rights reserved.
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