Journal
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
Volume 6, Issue 6, Pages 530-538Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S2040174415001440
Keywords
co-activator proteins; co-repressor proteins; maternal obesity; maternal undernutrition; peroxisome proliferator-activated receptors
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Funding
- National Institute of Diabetes and Digestive and Kidney Grants [R01DK081756]
- National Institute of Child Health and Human Development Grant [R01HD054751]
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We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPAR gamma) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60% kcal) or control (10% kcal) diet before mating, and throughout pregnancy and lactation (Mat-OB). Additional dams were 50% food-restricted from pregnancy day 10 to term [intrauterine growth-restricted (IUGR)]. Adipose tissue protein expression was analyzed in newborn and adult male offspring. Normal birth weight Mat-OB and low birth weight IUGR newborns had upregulated PPAR gamma with variable changes in co-repressors and co-activators. As obese adults, Mat-OB and IUGR offspring had increased PPAR gamma with decreased co-repressor and increased co-activator expression. Nutritionally programmed increased PPAR gamma expression is associated with altered expression of its co-regulators in the newborn and adult offspring. Functional studies of PPAR gamma co-regulators are necessary to establish their role in PPAR gamma-mediated programmed obesity.
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