Journal
REPRODUCTIVE TOXICOLOGY
Volume 35, Issue -, Pages 32-39Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2012.05.095
Keywords
Tetrabromobisphenol A; Fertility; Reproductive parameters; Spermatogenesis; Histopathology of testes; Apoptosis; Gene expression
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Funding
- Ministry of Education of the Czech Republic [2B06151, 1M06011]
- Ministry of Health of the Czech Republic [NS10009-4/2008]
- Grant Agency of Czech Republic [523/09/1793, 523/08/H064]
- [AV0Z 50520701]
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Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA. (C) 2012 Elsevier Inc. All rights reserved.
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