Journal
REPRODUCTIVE TOXICOLOGY
Volume 42, Issue -, Pages 224-231Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2013.09.008
Keywords
Bisphenol-A; Antral follicle count; Day-3 follicle stimulating hormone; Ovarian volume; Ovarian reserve
Categories
Funding
- National Institute for Environmental Health Sciences (NIEHS) [ES009718, ES000002, T32ES007069]
- National Institute for Occupational Safety and Health (NIOSH) [OH008578]
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In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (+/- GSD) of 1.6 +/- 2.0, 1.7 +/- 2.1, and 1.5 +/- 1.8 mu g/L for the women contributing to the AFC (n = 154), day-3 FSH (n = 120), and OV (n = 114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), -22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging. (C) 2013 Elsevier Inc. All rights reserved.
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