Journal
REPRODUCTIVE TOXICOLOGY
Volume 33, Issue 4, Pages 513-530Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.08.004
Keywords
Perfluorobutyrate (PFBA); Perfluorooctanoate (PFOA); Repeat-dose toxicity; Rats
Categories
Funding
- U.S. Environmental Protection Agency
Ask authors/readers for more resources
Sequential 28-day and 90-day oral toxicity studies were performed in male and female rats with ammonium perfluorobutyrate (NH(4)(+)PFBA) at doses up to 150 and 30 mg/kg-d, respectively. Ammonium perfluorooctanoate was used as a comparator at a dose of 30 mg/kg-d in the 28-day study. Female rats were unaffected by NH(4)(+)PFBA. Effects in males included: increased liver weight, slight to minimal hepatocellular hypertrophy: decreased serum total cholesterol: and reduced serum thyroxin with no change in serum thyrotropin. During recovery, liver weight, histological, and cholesterol effects were resolved. Results of RT-qPCR were consistent with increased transcriptional expression of the xenosensor nuclear receptors PPAR alpha and CAR as well as the thyroid receptor, and decreased expression of Cyp1A1 (Ah receptor-regulated). No observable adverse effect levels (NOAELs) were 6 and >150 mg/kg-d for male and female rats in the 28-day study and 6 and >30 mg/kg-d in the 90-dat study, respectively. (C) 2011 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available