Journal
REPRODUCTIVE TOXICOLOGY
Volume 34, Issue 4, Pages 644-650Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2012.09.007
Keywords
Perfluorooctanoic acid; Perfluorooctanesulfonate; Y:X chromosome ratio
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Funding
- European Commission [FP7-ENV-2008-1-226217, QLK4-CT-2001-00202]
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This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p = 0.845 in a linear model, p = 0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p = 0.016), with no association in a linear model (p = 0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B= -0.002, p= 0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men. (C) 2012 Elsevier Inc. All rights reserved.
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