Journal
REPRODUCTIVE TOXICOLOGY
Volume 31, Issue 1, Pages 1-9Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2010.09.009
Keywords
BPA; Bisphenol A; Prostate; Pharmacokinetics; Prostate intraepithelial neoplasia
Categories
Funding
- NIH [ES-015584]
- American Recovery and Reinvestment Act
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES006096, R01ES015584] Funding Source: NIH RePORTER
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The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10 mu g BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at C-max were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC(0-2) for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. vs. oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10 mu g BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T + E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels. (C) 2010 Elsevier Inc. All rights reserved.
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