Journal
REPRODUCTIVE TOXICOLOGY
Volume 30, Issue 3, Pages 477-480Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2010.05.007
Keywords
Lead; Pregnancy; Fetal membrane; Premature rupture of the membranes
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Funding
- Japanese National Institute of Occupational Safety and Health
- Japan Society for the Promotion of Science
- Tehran University of Medical Sciences
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To clarify the effects of lead on fetal premature rupture of the membranes (PROM), blood lead concentrations were measured using inductively coupled plasma-mass spectrometry in 332 women, aged 16-35 years, during their early pregnancy period (8-12 weeks). Blood lead concentrations were significantly higher in the 36 PROM deliveries than in the 296 non-PROM deliveries (mean +/- SD, 4.61 +/- 2.37 and 3.69 +/- 1.85 mu g/dl, respectively; p < 0.05). The logistic regression analysis revealed that a 1-unit increase in the logarithm of the blood lead level led to a several-fold increase in the risk of PROM (unit risk = 17.98, 95% CI 1.6-198.6). Thus, it is suggested that lead can increase the risk of PROM in pregnant women with mean blood lead less than 5 mu g/dl. (C) 2010 Elsevier Inc. All rights reserved.
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