Journal
REPRODUCTIVE TOXICOLOGY
Volume 30, Issue 4, Pages 625-634Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2010.08.004
Keywords
Bisphenol A; LHRH pre mRNA; Hypothalamus
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Funding
- Argentine National Council for Science and Technology (CONICET) [652/04]
- Argentine National Agency for the Promotion of Science and Technology (ANPCyT) [35565]
- Universidad Nacional del Litoral [019/118, 019/119]
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This study examines the effects of neonatal exposure to the endocrine disruptor bisphenol A (BPA) on the neural network that controls estrous cyclicity From postnatal day 1 (PND1) to PND7 female pups were injected with vehicle (control) or BPA (BPA 05 0 05 mg/kg-d BPA20 20 mg/kg-d) At PND100 BPA.05-females showed alterations in estrous cyclicity and BPA20-females were Incapable of producing an estradiol-induced LH surge By real-time PCR we determined that hypothalamic expression of mature LH-releasing hormone (LHRH) mRNA was increased in BPA 05 and decreased in BPA20-females Furthermore unprocessed intron A-containing LHRH RNA was decreased in the cytoplasm of hypothalamic cells of both groups Immunohistochemistry revealed that estrogen receptor alpha protein was up-regulated in anteroventral periventricular and down-regulated in arcuate nucleus of both groups Our results show that BPA permanently disrupts hypothalamic LHRH pre-mRNA processing and steroid receptors expression in nuclei that control estrous cyclicity in adult rats (C) 2010 Elsevier Inc All rights reserved
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