Journal
REPRODUCTIVE TOXICOLOGY
Volume 25, Issue 4, Pages 455-460Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2008.05.055
Keywords
oxons toxicity; methyl-parathion; chlorpyrifos; diazinon; sperm chromatin; sperm DNA
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Funding
- CONACyT-Mexico [44643]
- ESA
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Extensive use of organophosphorous pesticides (OP) by young men represents a public health problem. Toxicity of OP mainly results in neurotoxicity due to their oxygen analogues (oxons), formed during the OP oxidative activation. OP alter semen quality and sperm chromatin and DNA at different stages of spermatogenesis. Oxons are more toxic than the parent compounds; however, their toxicity to spermatogenic cells has not been reported. We evaluated sperm DNA damage by several OP compounds and their oxons in human spermatozoa from healthy volunteers incubated with 50-750 mu M of methyl-parathion (MePA), methyl-paraoxon (MePO), chlorpyrifos (CPF), chlorpyrifos-oxon (CPO), diazinon (DZN) or diazoxon (DZO). All concentrations were not cytotoxic (evaluated by eosin-Y exclusion), except 750 p,]VI MePO. Oxons were 15% to 10 times more toxic to sperm DNA(evaluated by the SCSA parameter, %DFI) than their corresponding parent compounds, at the following order: MePO > CPO = MePA > CPF > DZO > DZN, suggesting that oxon metabolites participate in OP sperm genotoxicity. (C) 2008 Elsevier Inc. All rights reserved.
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