Journal
REPRODUCTIVE TOXICOLOGY
Volume 25, Issue 3, Pages 316-326Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2008.03.002
Keywords
organochlorines; female reproductive tract; human; laboratory and farm animals
Categories
Ask authors/readers for more resources
The present paper summarizes the toxicological data on the effects of the organochlorine pesticides DDT, its metabolites, TCPM, methoxychlor and linclane on folliculogenesis, ovulation, fertilization, and implantation of female reproductive organs in human, laboratory, and farm animals. These compounds possess the ability to disrupt endogenous hormone synthesis, storage or metabolism. Cells of the ovary, oviduct, and uterus are susceptible to the disruptive effects of organochlorine compounds (OCCs). This review discusses that the exposure to OCC causes an impairment of(l) female fertility by altering ovarian development and function and (2) implantation by altering endometrial function through their estrogenic activity. The main focus of this review is to provide an overview on data which support that assumption that OCC can substitute for estradiol in regulating the microanatomy of the female reproductive tract. The data indicate the potential of these compounds act as endocrine disrupting agents, but in a different extent. (c) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available