Journal
REPRODUCTIVE TOXICOLOGY
Volume 26, Issue 3-4, Pages 303-309Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2008.09.003
Keywords
Aflatoxin; Aneuploidogeny; Male reproductive toxicity; Meiotic arrest; Meiotic micronuclei; Microtubule disassembly; Spindle; Testis
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Funding
- Department of Science and Technology (DST), Government of India, New Delhi [SRISO/AS-59/2004]
- DST under FIST scheme [SR/FST/LSI-112/2002]
- University Grants Commission (UGC), New Delhi [F.3-5/2007]
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Dietary aflatoxins produce a disease state known as aflatoxicosis, and disruption of spermatogenesis is one of its serious consequences. Towards finding the cellular targets in spermatogenic compartment for aflatoxin toxicity, aflatoxin B-1 (AFB(1)) was administered to 90-day-old Swiss mouse through i.p. route at a daily dose of 20 mu g per kg body weight for 7, 15, 35 and 45 days. The testis and epididymis were subjected to light- as well as transmission electron microscopic analysis. One of the newer observations was occurrence of meiotic micronucleate giant spermatocytes in seminiferous epithelium and epididymal lumen. The origin of these cells could be traced to imminent disruption of spindle apparatus during meiotic division of spermatocytes, resulting in lagging of chromosome bivalents or replicated univalents. Such chromosomes appeared to undergo condensation and become micronuclei. Thus, this study reports that aflatoxin exposure would result in generation of meiotic micronucleate giant spermatocytes. (C) 2008 Elsevier Inc. All rights reserved.
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