Journal
REPRODUCTIVE SCIENCES
Volume 17, Issue 5, Pages 434-443Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719110361384
Keywords
Endometrium; implantation; uterine receptivity
Categories
Funding
- National Center for Research Resources, National Institutes of Health [C06 RR16515-01]
- Eunice Kennedy Shriver NICHD/NIH [U54 HD 055787, HD 040093]
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During early pregnancy, the endometrium undergoes pronounced hormone-dependent functional changes in preparation for embryo implantation. Local autocrine-paracrine signaling at the fetal-maternal interface is crucial for the establishment of pregnancy. We previously reported that the transcription factor C/EBP beta, which is expressed at the implantation sites (ISs) in pregnant mice, acts as a key mediator of steroid hormone responsiveness in the endometrium. Mice lacking C/EBP beta fail to support implantation due to defects in epithelial proliferation and stromal cell differentiation. In the current study, C/EBP beta expression was dramatically stimulated in the endometrium of baboons (Papio anubis) during the window of uterine receptivity in response to a local infusion of chorionic gonadotropin, an embryonic signal. A robust induction of C/EBP beta expression was also seen at the IS in the baboon and the human. Collectively, our results indicate that C/EBP beta is a biomarker of endometrial receptivity and plays a conserved functional role during implantation in the primate.
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