Is 45 years-of-age the cut-off for using autologous oocytes?

A case report published in this issue of RBMO (Gleicher et al., 2018) invites a philosophical debate around two women, both aged 47 years, who became pregnant from autologous oocytes, one progressing to a pre-term livebirth at 35 weeks, by which time the mother was 48 years old. Each woman received adjuvants, either dehydroepiandrosterone (DHEA) or growth hormone (GH). The case report also notes two further livebirths in 2016 in women aged 45 years. from further autologous attempts. Certainly, for those who will accept the proposal, donor oocytes from younger women can provide a higher chance of livebirth and this is probably best undertaken at the 'youngish' age of 45-49 years, prior to established menopause.