AMH concentration is not related to effective time to pregnancy in women who conceive naturally

This study determined whether anti-Mullerian hormone (AMH) concentration influences the time necessary to conceive a live-born child - effective time to pregnancy (eTTP) - in a population of women who conceived naturally. This is an observational study of 87 women with a planned spontaneous pregnancy resulting in a live birth. eTTP was assessed retrospectively by a questionnaire and AMH was measured in a frozen serum sample from first trimester of pregnancy. eTTP was correlated with age (r = -0.24, P = 0.02), but not with AMH (r = -0.10) or body mass index (r = 0.05). With logistic regressions, the only variable that affected the probability of pregnancy within 3 or 6 months was age, irrespective of whether an AMH concentration limit of 1.0 ng/ml or 2.0 ng/ml was chosen. In conclusion, this study suggests that there is no relationship between AMH concentration and eTTP and therefore speaks against determining AMH in women who are not infertile for the purpose of predicting their chances of pregnancy. The findings are concordant with previous reports describing AMH as a quantitative but not a qualitative marker of ovarian reserve and therefore does not reflect a woman's ability to become pregnant. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.