Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 27, Issue 5, Pages 497-505Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2013.06.010
Keywords
embryo implantation; endometrium; oestradiol; progesterone
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Funding
- NICHD NIH HHS [R01 HD067721] Funding Source: Medline
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Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. Experience with assisted reproduction, especially oocyte donation cycles, has established that despite the diverse set of hormones produced by the ovary in a cycle- dependent fashion, the sequential actions of only two of them, oestrogen and progesterone, are sufficient to prepare a highly receptive endometrium in humans. Further investigation on the endometrial actions of these two hormones is currently providing significant insight into the implantation process in women, strongly suggesting that an abnormal response to progesterone underlies infertility in some patients. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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