Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 27, Issue 1, Pages 104-106Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2013.03.017
Keywords
mutation; P27; premature ovarian failure; single-nucleotide polymorphism; SKP2
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Funding
- National Basic Research Program of China (973 Program) [2012CB944700, 2011CB944502]
- National Natural Science Foundation of China [81000236, 81100417]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [201078]
- Independent Innovation Foundation of Shandong University, IIFSDU [2012TS130]
- Graduate Independent Innovation Foundation of Shandong University (GIIFSDU) [21300070613080]
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P27 and SKP2, a major regulator of P27, play a crucial role in ovarian function in mice. Both P27-deficient and SKP2-deficient female mice develop premature ovarian failure (POF). The coding regions of SKP2 and P27 were examined in 200 Chinese women with POF and 200 control volunteers. This study is the first to investigate SKP2 in POF. No plausible pathogenic mutations were detected. The results suggest that mutations in SKP2 and P27 are not common in Chinese Han women with POF. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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