Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 24, Issue 2, Pages 211-218Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2011.10.006
Keywords
DNA fragmentation; high magnification; male infertility; sperm chromatin decondensation; sperm head morphology
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The utility of sperm DNA testing remains controversial. However, it may be helpful in couples with unexplained failures of multiple assisted reproductive techniques and/or recurrent abortions. This study analysed 10,400 spermatozoa of 26 patients for sperm-head morphology with high-magnification microscopy, DNA fragmentation and sperm chromatin decondensation. A significant negative correlation was demonstrated between sperm-parameters and abnormal sperm-head morphology as assessed by high magnification (score 0 according to this study's classification): concentration (r = -0.41; P = 0.03), motility (r = -0.42; P = 0.03), morphology (r = -0.63; P = 0.0008). No correlation was found with DNA fragmentation. However, the sperm chromatin-decondensation rate of score-0 spermatozoa was twice as high as the controls (19.5% versus 10.1%; P < 0.0001). This observation suggests that score-0 spermatozoa should not be selected for intracytoplasmic sperm injection. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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