Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 18, Issue 1, Pages 120-126Publisher
REPRODUCTIVE HEALTHCARE LTD
DOI: 10.1016/S1472-6483(10)60433-6
Keywords
aneuploidy rescue; human embryonic stem cells; in-vitro fertilization; non-disjunction; polar body diagnosis; preimplantation genetic diagnosis
Categories
Ask authors/readers for more resources
At least 50-60% of oocytes derived from IVF procedures are chromosomally abnormal due to meiotic I or II errors. Through the use of polar body and blastomere diagnosis, euploid embryos Suitable for transfer can be identified. Those embryos that are aneuploid are usually discarded, or otherwise can be used to generate chromosomally abnormal human embryonic stem cell (hESC) lines. The authors' centre has one of the largest repositories of hESC lilies with genetic and chromosomal disorders generated from preimplantation genetic diagnosis (PGD) abnormal embryos. The results, studying hESC lilies derived from PGD abnormal zygotes, imply that aneuploidies resulting from meiotic non-disjunction have a greater impact on viability of cells of the human embryos than those originating from post-zygotic mitotic non-disjunction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available