Journal
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
Volume 12, Issue -, Pages 1-11Publisher
BMC
DOI: 10.1186/1477-7827-12-111
Keywords
Mitochondria; Oocytes; Embryos; Embryo development; Metabolism; In vitro fertilization; Mitochondrial supplementation; Infertility treatment
Categories
Ask authors/readers for more resources
Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte quality which is important for fertilization and development into viable offspring. Quality-compromised oocytes are correlated with infertility, developmental disorders, reduced blastocyst cell number and embryo loss in which mitochondrial dysfunctions play a significant role. Increasingly, women affected by metabolic disorders such as diabetes or obesity and oocyte aging are seeking treatment in IVF clinics to overcome the effects of adverse metabolic conditions on mitochondrial functions and new treatments have become available to restore oocyte quality. The past decade has seen enormous advances in potential therapies to restore oocyte quality and includes dietary components and transfer of mitochondria from cells with mitochondrial integrity into mitochondria-impaired oocytes. New technologies have opened up new possibilities for therapeutic advances which will increase the success rates for IVF of oocytes from women with compromised oocyte quality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available