Journal
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1477-7827-10-92
Keywords
Cytoplasmic droplet; Excess residual cytoplasm; Midpiece; Spermiogenesis; Cytoplasmic extrusion; Residual body; Regulatory volume decrease; Reactive oxygen species; Oxidative stress; Peroxidative damage
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Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. This review attempts to clarify excess residual cytoplasm's effect on fertility, examine the enzymes responsible, and suggest tests and possible treatment options for those affected by this defect.
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