Journal
REPRODUCTION FERTILITY AND DEVELOPMENT
Volume 21, Issue 4, Pages 599-607Publisher
CSIRO PUBLISHING
DOI: 10.1071/RD08224
Keywords
allopregnanolone; betamethasone; maternal asthma; placenta; preterm birth
Categories
Funding
- Hunter Medical Research Institute
- National Health and Medical Research Council of Australia [455527]
- National Health and Medical Research Council of Australia
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5 alpha-Reduced steroids, including allopregnanolone, suppress neuronal activity and can have neuroprotective effects in the fetus. 5 alpha-Reductases in the placenta may contribute precursors to brain allopregnanolone synthesis. Preterm birth and glucocorticoids, administered for fetal lung maturation or for maternal asthma, may influence reductase expression. The aims of the present study were to evaluate placental 5 alpha-reductase isoform expression during late gestation and to examine fetal sex differences and the effects of glucocorticoid therapies on the expression of these enzymes. Expression of the two 5 alpha-reductase isoenzymes was measured in placental samples, whereas cortisol concentrations were measured in cord blood, from two cohorts. The first cohort consisted of women who delivered preterm and received betamethasone treatment (n = 41); the second cohort consisted of women who delivered at term and were either healthy controls (n = 30) or asthmatics who had used glucocorticoids (n = 24). Placental expression of both isoenzymes increased with advancing gestation and there were marked sex differences in levels of 5 alpha-reductase I (P < 0.05), but not of 5 alpha-reductase II. The expression of both enzymes was positively correlated with cortisol levels (P < 0.05), but there was no effect of recent glucocorticoid exposure. These findings suggest that the preterm neonate may have lower developmental exposure to 5 alpha-reduced steroids and may lack steroid-mediated neuroprotection depending on fetal sex.
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