Journal
RENAL FAILURE
Volume 30, Issue 2, Pages 215-217Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08860220701813335
Keywords
VEGF; endostatin; angiogenesis; chronic kidney disease; circulating endothelial cell (CEC)
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Background. A progressive reduction in peritubular capillary flow is observed in chronic kidney disease (CKD) patients as the disease severity progresses. This suggests an altered vascular homeostasis in CKD patients, but such a defective mechanism needs to be verified. Methods. To study the vascular injury as reflected by circulating endothelial cell (CEC), the balance between angiogenic factor, vascular endothelial growth factor (VEGF), and antiangiogenic factor, endostatin. Results. A deficient VEGF was observed, whereas the value of endostatin and CEC were abnormally elevated in CKD patients. Discussion. Enhanced CEC reflects an increased activity of vascular injury. A deficient VEGF in the presence of enhanced antiangiogenesis (endostatin) implies a defective angiogenesis. This may explain the progressive nature of renal microvascular disease observed in late stage of CKD patients.
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