Journal
REJUVENATION RESEARCH
Volume 13, Issue 4, Pages 439-444Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/rej.2009.0992
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Funding
- Ghent University [01106205]
- Flanders-China [011S605]
- Institute Born-Bunge
- Institute Born-Bunge-University of Antwerp
- International Alzheimer Research Foundation
- Belgian Federal Science Policy Office [P6/43]
- Flemish Government
- Medical Research Foundation Antwerp
- Neurosearch Antwerp
- Thomas Riellaerts Research Fund
- Research Foundation-Flanders (FWO-F) [G.0127.07]
- Institute for Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- UNESCO-L'Oreal for Women in Science
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We investigated whether blood N-glycan changes can be used as a diagnostic biomarker for Alzheimer disease (AD). We used DNA sequencer-assisted, fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology to assay N-glycans in sera from 79 autopsy-confirmed dementia patients and 149 healthy controls. One N-glycan (NA2F) was substantially decreased in AD patients but not in controls. Use of NA2F for discriminating AD between dementia patients and healthy controls showed a diagnostic accuracy of 85.7% +/- 2.8% with 92% specificity and 70% sensitivity. The decrease in the level of NA2F in AD patients compared to non-AD patients was more pronounced in females (p < 0.0001) than in males (p < 0.014). Use of NA2F to differentiate female AD from female non-AD patients reached a diagnostic accuracy of 90.7% +/- 4.8 %. Pearson correlation analysis showed that in female dementia patients, serum NA2F levels were significantly correlated with the cerebrospinal fluid (CSF) beta-amyloid peptide of 42 amino acids (A beta(1-42)) and tau phosphorylated at threonine 181 (P-tau(181P)) levels, whereas in male dementia patients serum NA2F levels were significantly correlated only with CSF total tau protein (T-tau) level. Thus, we suggest that the serum N-glycan marker might be suitable for longitudinal and follow-up studies.
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