Journal
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
Volume 14, Issue 1, Pages 92-94Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534734615570360
Keywords
prolidase deficiency; leg ulcer; hydrocolloid gel
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Prolidase deficiency (PD) is a rare autosomal recessive disorder that has symptoms such as skin ulcers, characteristic facies, mental retardation, skeletal deformities, hematological anomalies, splenomegaly, and chronic infections. Deficiency of prolidase leads to the increased excretion of proline in urine, which causes impaired collagen synthesis and delay in wound healing. This case reports a 40-year-old female who has had cutaneous ulcers since the age of 7 years. We also recognized borderline intellectual functioning as well as hematologic abnormalities and splenomegaly. We present this rare case to draw attention to consider prolidase deficiency in the differential diagnosis of leg ulcers.
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