Journal
REGULATORY PEPTIDES
Volume 183, Issue -, Pages 42-45Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2013.03.019
Keywords
Oxytocin receptor (OTR); Real-time RT-PCR; Immunohistochemistry; Islets of Langerhans; A-cells; B-cells
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In this study, oxytocin receptors (OTRs) in the islets of Langerhans were detected using real-time RT-PCR and immunohistochemical technique. Indeed, OTR mRNA was expressed in the rat pancreas. Double immunohistochemical staining for OTR and either glucagon or insulin demonstrated their co-localization in A-cells or B-cells, respectively. OTR-immunoreactivity in A-cells was stronger than that of B-cells. All A-cells and 94.8% of B-cells were OTR-immunoreactive. We reveal the statistically significant relations of 0112 with A-cells and B-cells in the islets of Langerhans. This is the first demonstration of the OTR localization in the islets of Langerhans immunohistochemically. It suggests that oxytocin (OT) is involved in the release of insulin and glucagon. (C) 2013 Elsevier B.V. All rights reserved.
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