Neuroprotective properties of L-carnosine in the brain slices exposed to autoblood in the hemorrhagic stroke model in vitro

Neuroprotective properties of L-carnosine have been studied in our in vitro model on olfactory cortex slices of hypertensive rats under a long autoblood (blood clot) influence. Application of L-carnosine (5 mg/ml) on slices before autoblood influence leads to restoration of the activity of glutamatergic and GABA-ergic receptors inhibited in the presence of autoblood and interferes with swelling of slices. L-Carnosine protects a bioelectric activity of nervous cells in case of long influence of autoblood and also renders an anti edema effect. This model of hemorrhagic stroke may provide a perspective for investigating the mechanisms of neuroprotection. Published by Elsevier B.V.