Journal
REGULATORY PEPTIDES
Volume 147, Issue 1-3, Pages 1-3Publisher
ELSEVIER
DOI: 10.1016/j.regpep.2007.11.006
Keywords
orexin; hypocretin; immunohistochemistry; enteric nervous system
Categories
Funding
- NHLBI NIH HHS [HL60292, P50 HL060292-070005, P50 HL060292, P50 HL060292-100005] Funding Source: Medline
- NINDS NIH HHS [NS055367, R01 NS055367-07, R01 NS055367] Funding Source: Medline
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Hypocretins (orexins) are wake-promoting neuropeptides produced by hypothalamic neurons. These hypocretin-producing cells are lost in people with narcolepsy, possibly due to an autoimmune attack. Prior studies described hypocretin neurons in the enteric nervous system, and these cells could be an additional target of an autoimmune process. We sought to determine whether enteric hypocretin neurons are lost in narcoleptic subjects. Even though we tried several methods (including whole mounts, sectioned tissue, pre-treatment of mice with colchicine, and the use of various primary antisera), we could not identify hypocretin-producing cells in enteric nervous tissue collected from mice or normal human subjects. These results raise doubts about whether enteric neurons produce hypocretin., (C) 2007 Elsevier B.V. All rights reserved.
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