Journal
REGENERATIVE MEDICINE
Volume 4, Issue 1, Pages 65-80Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17460751.4.1.65
Keywords
angiogenesis; angiogenic therapy; growth factor; therapeutic vascularization; VEGF
Categories
Funding
- NIBIB NIH HHS [R01 EB004496, R01 EB004496-04] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB004496] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The ability to exploit angiogenesis and vascularization as a therapeutic strategy will be of enormous benefit to a wide range of medical and tissue-engineering applications. Angiogenic growth factor and cell-based therapies have thus far failed to produce a robust healing response in clinical trials for a variety of ischemic diseases, while engineered tissue substitutes are still size-limited by a lack of vascularization. The purpose of this review is to investigate current research advances in therapeutic vascularization strategies applied to ischemic disease states, tissue engineering and regenerative medicine. Recent advances are discussed that focus on better regulation of growth factor delivery and attempts to better mimic natural processes by delivering combinations of multiple growth factors, cells and bioactive materials in the right spatial and temporal setting. Some unconventional approaches and novel therapeutic targets that hold significant potential are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available