Journal
REACTIVE & FUNCTIONAL POLYMERS
Volume 82, Issue -, Pages 89-97Publisher
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2014.06.005
Keywords
Biodegradable; Micelles; Depsipeptide; Drug release; Doxorubicin
Funding
- National Natural Science Foundation of China [31370969]
- International Cooperation from Ministry of Science and Technology of China [2013DFG52040, 2008DFA51170]
- Ph.D. Programs Foundation of Ministry of Education of China [20120032110073]
- Program of Introducing Talents of Discipline to Universities of China [B06006]
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Nowadays, biodegradable amphiphilic block copolymers with stable performance and adjustable structure have attracted the interests of researchers in the field of drug delivery. In this work, the triblock copolymer, P(SBMD-co-PDO)-b-PEG-b-P(SBMD-co-PDO), was successfully synthesized by ring-opening polymerization of 3(S)-sec-butyl-morpholine-2,5-dione (SBMD) and p-dioxanone (PDO) with poly(ethylene glycol) (PEG) as the initiator. In phosphate buffered solution (PBS), these copolymers could self-assemble into nano-sized micelles that have a hydrophobic P(SBMD-co-PDO) core surrounded by a hydrophilic PEG shell. Because of the strong hydrogen bonding and hydrophobic interactions, doxorubicin (DOX) was loaded into the micelles with high loading capacity (LC, up to 28.4%) and encapsulation efficiency (EE, up to 62.5%). The drug-loaded micelles showed sustained-release of DOX along with the hydrolytic degradation of the micelles in PBS. Therefore, these amphiphilic triblock copolymers have potential as drug matrix for controlled release. (C) 2014 Elsevier Ltd. All rights reserved.
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