Journal
REACTIVE & FUNCTIONAL POLYMERS
Volume 72, Issue 5, Pages 329-336Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2012.03.007
Keywords
Mesoporous silica nanospheres; Magnetite; Poly(acrylic acid); Magnetic resonance imaging; Drug delivery
Funding
- National Natural Science Foundation of China [50972092, 20971086]
- Shanghai Key Laboratory of the Rare Earth Functional Materials [07dz22303]
- Education Ministry of China [210075]
- Shanghai Municipal Education Commission [10ZZ84]
Ask authors/readers for more resources
Multi-functional magnetic mesoporous silica nanospheres (MMSNs), which were coated with poly(acrylic acid) (PM), have been synthesized using the atom transfer radical polymerization of tert-butyl acrylate on the surface of MMSNs followed by the hydrolysis of the grafted poly(tert-butyl acrylate) chains. The resulting MMSN-PAA nanocomposites exhibit negligible cytotoxicity toward HeLa and L02 cells. Magnetic resonance imaging (MRI) studies reveal that the nanocomposites can be effectively taken-up by the cancer cells. The anticancer drug doxorubicin hydrochloride (DOX) can be loaded into the nanocomposites and subsequently released in a sustained and pH-responsive way because of the presence of pH-sensitive polymer shells. The DOX-loaded nanocomposites exhibit notable cytotoxicity to HeLa cancer cells. These results demonstrate that the pH-responsive MMSN-PAA nanocomposites can be applied to biological systems for MRI and drug delivery. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available