Journal
REACTIVE & FUNCTIONAL POLYMERS
Volume 70, Issue 10, Pages 767-774Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2010.07.016
Keywords
Reactive methacrylates; Atom transfer radical polymerization; Free radical polymerization; Functional poly(methacrylate)s; Bioconjugation
Funding
- European Commission [BIOPRODUCTION/NMP-2-T-2007-026515]
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Three reactive polymers, poly(para-nitrophenoxycarbonyloxyethyl methacrylate-co-methyl methacrylate) P(p-NPCEMA-co-MMA) [rCoP1], poly(methyl methacrylate-co-butyl methacrylate-co-allyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-BMA-co-AMA-co-PCEMA) [rCoP2) and poly(methyl methacrylate-co-dimethylaminopropyl methacrylate-co-dodecyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-DMAPMA-co-DMA-co-PCEMA) [rCoP3], respectively, were prepared following two synthetic concepts. Following the first concept, p-NPCEMA and PCEMA were prepared starting with commercially available HEMA and were copolymerized via ATRP with MMA, BMA and AMA. According to the second concept phenoxycarbonyloxy decorated polymethacrylates were obtained via polymer analogous reaction of a HEMA containing functional polymethacrylate, P(MMA-co-DMAPMA-co-DMA-co-HEMA) [fCoP], obtained via a cascade reaction of enzymatic transacylation and free radical polymerization. The highly reactive poly(methacrylate)s and silk peptides, hen egg-white lysozyme and Candida antarctica lipase B were used for the preparation of protein/peptide-poly(methacrylate) bioconjugates. (C) 2010 Elsevier Ltd. All rights reserved.
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