Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 25, Issue 24, Pages 3690-3696Publisher
WILEY
DOI: 10.1002/rcm.5281
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Funding
- Areas of Excellence (AoE) Scheme [AoE/P-10/01]
- Special Equipment Grant [SEG_HKU02]
- Strategic Research Theme (SRT) on Drug
- Hong Kong Research Grants Council [HKU_704511]
- National Cancer Institute (USA) [UO1-CA63477]
- National Institute of Health (USA)
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Gold nanoparticles (AuNPs) were applied and optimized as matrix for matrix-assisted laser desorption/ionization mass spectrometry analysis of animal tissues, and enabled histological analysis of animal tissues at molecular level by imaging mass spectrometry (IMS). AuNPs were coated on animal tissue in a solvent-free manner via argon ion sputtering. Metabolites, including neurotransmitters, fatty acids and nucleobases, were directly detected from mouse brain tissue. Based on region-specific chemical profiles, fine histological features of mouse brain tissue and heterogeneous regions of tumor tissue were both revealed. Copyright (C) 2011 John Wiley & Sons, Ltd.
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