Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 24, Issue 17, Pages 2569-2574Publisher
WILEY
DOI: 10.1002/rcm.4677
Keywords
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Funding
- Genomics Research Center, Academia Sinica
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To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright (C) 2010 John Wiley & Sons, Ltd.
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